3-Carboxyphenylboronic Acid CAS 25487-66-5: Properties, Uses, and Buying Guide

3-Carboxyphenylboronic acid, CAS 25487-66-5, is an aromatic boronic acid bearing a carboxylic acid group at the 3-position of the phenyl ring. Its two functional groups make it a useful building block for synthetic chemistry, particularly when a project needs to introduce a carboxyl-containing aromatic unit through carbon–carbon bond formation. The molecular formula is C₇H₇BO₄, and the molecular weight is approximately 165.94 g/mol. Below, we explain its identity, typical applications, purchasing considerations, and the information buyers should request from a supplier.

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Key Takeaways

• 3-Carboxyphenylboronic acid combines an aryl boronic acid group with a carboxylic acid group in a meta-substituted structure.
• It is commonly considered as a building block for Suzuki–Miyaura cross-coupling and related research or intermediate-development work.
• Buyers should confirm the required assay, impurity profile, documentation, packaging, and delivery terms for their specific application.
• Maison Chemical can discuss product requirements and sourcing needs with B2B buyers; availability and commercial terms should be confirmed for each inquiry.

Who This Guide Is For

This guide is intended for procurement teams, process chemists, research groups, and chemical distributors evaluating 3-Carboxyphenylboronic acid. It is especially relevant when a project requires a substituted arylboronic acid as a starting material or intermediate. The information can support early-stage specification development, but it does not replace project-specific analytical review. Buyers should align material requirements with their own process, quality system, and regulatory obligations.

Basic Identity and Chemical Context

Structure and Functional Groups

The molecule contains a phenyl ring with a boronic acid substituent and a carboxylic acid substituent positioned meta to one another. The boronic acid group can participate in palladium-catalyzed coupling reactions, while the carboxyl group provides a separate point for further chemical transformation. This combination can support synthetic sequences in which the aromatic ring is coupled first and the acid functionality is retained or modified later. Actual reaction suitability depends on the substrate, reaction conditions, and downstream chemistry.

Properties Buyers Should Verify

Commercial specifications can vary by supplier, grade, and production or sourcing route. Before ordering, request a current specification and certificate of analysis (CoA) that identify the tested material and the analytical methods used. Confirm assay and relevant impurity limits rather than assuming that a catalog description represents the exact grade your process requires. Appearance, solubility, storage guidance, and retest or expiry information should also be confirmed in the product documentation.

Uses and Application Matching

Synthetic Chemistry and Cross-Coupling

A key application area is Suzuki–Miyaura cross-coupling, where an arylboronic acid may serve as the organoboron partner for forming a carbon–carbon bond. The carboxyl group can make this compound useful when the desired product needs an aromatic acid substituent or a functional group for later derivatization. Researchers may evaluate it in pharmaceutical intermediate development, specialty organic synthesis, or other research programs that use substituted aromatic building blocks. These are application areas, not guarantees that the material will perform under any particular reaction conditions.

Choosing It for a Project

Match the compound to the intended route by checking whether the meta relationship between the two substituents is required in the target structure. Review the planned coupling partner, catalyst system, solvent, and work-up with a qualified chemist, because these variables can influence conversion and impurity formation. If the project depends on the acid group remaining intact, include that requirement in reaction planning and analytical testing. For a new route, consider a small evaluation order before committing to a larger quantity.

Buyer Selection Framework

Define the Specification Before Requesting a Quote

Start by stating the intended use, target assay, acceptable impurity profile, and any specific analytical or documentation requirements. If you have a validated internal specification, share it with the supplier so that feasibility can be assessed before order confirmation. Where no specification exists, ask for the supplier’s available grade details and review them with your technical and quality teams. Avoid relying on assay alone if trace impurities or water content could affect your chemistry.

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Evaluate Quantity, Packaging, and Documentation

Request a quotation for the quantity you need and confirm whether the supplier can support the required pack size. As a planning example—not a statement of Maison Chemical’s minimum order quantity—a buyer might first evaluate 1–5 g for laboratory screening and then consider 10–100 g for route or process assessment. Actual sample availability, MOQ, packaging, and lead time must be confirmed directly. Ask whether the shipment can be accompanied by a CoA and safety data sheet (SDS), and clarify any additional documentation needed for internal review or import.

Understand Pricing and Lead-Time Factors

Pricing can depend on requested quantity, grade, packaging, availability, and the documentation or testing required. Lead time may also vary with stock status, sourcing route, order size, and destination. For a usable comparison, request a quote that states the quoted quantity, currency, validity period, delivery basis, and estimated dispatch timing. Treat these details as order-specific rather than assuming that an online listing reflects current commercial terms.

Supplier Evaluation Checklist

A reliable sourcing review should establish whether the offered material matches the required identity and whether the supplier can provide the records needed for your purchasing process. Ask questions before placing an order, especially if the compound is a critical intermediate or the project has strict impurity controls. Compare suppliers using the same specification and delivery assumptions so that the assessment is meaningful. Confirm all final terms in writing before purchase.

• Does the product identity and CAS number match the requested material?
• Is a current specification available, with assay and relevant impurity criteria?
• Can the supplier provide a batch-specific CoA and an SDS?
• Are the pack size, packaging method, and handling information suitable for the intended use?
• Are MOQ, price, lead time, shipping terms, and document requirements clearly stated?
• Can the supplier explain how questions about quality or order documentation will be handled?

Common Purchasing Mistakes

One common mistake is selecting a product by name alone without checking the CAS number and specification. Another is treating a quoted assay as a complete quality profile, even when the process may be sensitive to particular impurities. Buyers can also overlook packaging and transport requirements or assume that a sample, a larger lot, and a future repeat order will have identical availability. Clarifying these points at the inquiry stage helps reduce avoidable delays and specification mismatches.

Working with Maison Chemical

At Maison Chemical, we work with B2B buyers evaluating chemical intermediates and can discuss requirements for 3-Carboxyphenylboronic acid, CAS 25487-66-5. To help us assess an inquiry, include your target quantity, required assay or specification, destination, preferred packaging, and documentation needs. We can then confirm current availability and provide applicable quotation and product information for review. Any supply, sample, lead-time, or customization details remain subject to confirmation for the specific order.

Conclusion and Next Steps

3-Carboxyphenylboronic acid is a meta-substituted aromatic building block that combines a boronic acid group with a carboxylic acid group, making it a candidate for cross-coupling and other synthetic applications. Its core identity is described by CAS 25487-66-5, formula C₇H₇BO₄, and molecular weight approximately 165.94 g/mol. To decide whether it fits your project, verify the structure, specification, analytical documentation, and compatibility with your intended route. Send Maison Chemical your quantity, quality requirements, and delivery destination to request current supply information and a project-specific quotation.